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Oxalic Acid → Rifampicin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalic Acid | HCID 971 | — |
| 反応物 | 1,3,5-Tris(1,1-dimethylethyl)hexahydro-1,3,5-triazine | HCID 66352 | — |
| 反応物 | 1-Amino-4-methylpiperazine | HCID 81349 | — |
| 反応物 | Rifamycin S | HCID 6436726 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Rifampicin | HCID 135398735 | — |
反応手順
0.36 g. Oxalic acid and 1.0 g. 1,3,5-tri-(tert.-butyl)-hexahydro-1,3,5-triazine are added to a solution of 2.8 g. rifamycin S in 10 ml. dimethylformamide. The mixture is kept at 75° C. for about 1 hour, then 1.7 g. of acidified 1-amino-4-methylpiperazine are added directly, according to the process described in Example 7. The chloroform extract finally obtained is concentrated to a small volume and diluted with an appropriate mixture of ethyl acetate-acetone to give a high yield of pure rifampicin.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04174320 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-1b42b8aa694d4037aa028ed71dae40f2 |
| 出典メモ | uspto-grants-1979_11 |