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Benzaldehyde → 7-Benzylidenamino-1-ethyl-2-methyl-5-trifluoromethyl-6-chlorobenzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Benzenesulfonic Acid | HCID 7371 | — |
| 反応物 | 6-Chloro-1-ethyl-2-methyl-5-(trifluoromethyl)-1H-benzimidazol-7-amine | HCID 14281419 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 7-Benzylidenamino-1-ethyl-2-methyl-5-trifluoromethyl-6-chlorobenzimidazole | HCID 20385381 | 94% |
反応手順
Benzaldehyde (0.78 g.; 7.35 mmole) was reacted with 1-ethyl-2-methyl-5-trifluoromethyl-6-chloro-7-aminobenzimidazole (1.0 g.; 3.66 mmole) in the presence of 7 ml. of xylene and a few crystals of benzenesulfonic acid. The mixture was refluxed for 1 hour, removing water from the reaction mixture. Upon cooling to room temperature, the product crystallized out of solution to give 1.24 g. (94% yield). After recrystallization from benzene, the product melts at 183°-185.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04174959 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-dee3b648626c42eaa7460360357e10a3 |
| 出典メモ | uspto-grants-1979_11 |