Ethanol → HCID 14699637、化合物
反応式
[F:1][C:2]1([Cl:9])[CH2:4][C:3]1([CH3:8])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:15](O)[CH3:16]>>[F:1][C:2]1([Cl:9])[CH2:4][C:3]1([CH3:8])[C:5]([O:7][CH2:15][CH3:16])=[O:6]参加物
4
実験手順
44 ml of ethanol are added at room temperature and with stirring to 43 g (0.28 mol) of 2-fluoro-2-chloro-1-methyl-cyclopropanecarboxylic acid. After the addition of sulphuric acid, the reaction mixture is refluxed for 16 hours. Excess ethanol is subsequently distilled off and the residue is dried and distilled under reduced pressure. In this manner, 40 g (79% of theory) of ethyl 2-fluoro-2-chloro-1-methyl-cyclopropane-carboxylate are obtained in the form of a liquid of boiling point 62-63° C./ 17 mbzr.
後処理
- temperaturethe reaction mixture is refluxed for 16 hours
- distillationExcess ethanol is subsequently distilled off
- customthe residue is dried
- distillationdistilled under reduced pressure
出典と根拠
- ORDレコード
- ord-59aae24601d242cc81d849ca2dccf218
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05159111
反応ノート
読み込み中…