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1,3-Dibromopropane → 1-(3-Bromopropoxy)-4-fluorobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Dibromopropane | HCID 8001 | — |
| 反応物 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 反応物 | 4-Fluorophenol | HCID 9732 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(3-Bromopropoxy)-4-fluorobenzene | HCID 260004 | — |
反応手順
A mixture of 11.2 g (0.1 mol) of 4-fluorophenol, 16.5 g (0.12 mol) of pulverized potassium carbonate, 20.2 g (0.1 mol) of 1,3-dibromopropane and 100 ml of anhydrous dimethoxyethane was refluxed under nitrogen for 6 hours and then cooled. The mixture was diluted with methylene chloride and washed with water. The resultant organic product solution was dried over Na2SO4 and evaporated in vacuo. The residue was chromatographed on silica gel using cyclohexane elution to give pure product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05159097 |
| 出典データセット | uspto-grants-1992_10 |
| ORD ID | ord-60b5ca190a014fdba9710dfad12d80e0 |
| 出典メモ | uspto-grants-1992_10 |