Dicyclohexylcarbodiimide → Boc-Cys(MBzl)-Phe-betaAla-OH
反応式
[NH:1]([C:18]([O:20]C(C)(C)C)=O)[C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH:25]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[C@H:26](C(O)=O)[CH2:27][S:28][CH2:29][C:30]1[CH:36]=[CH:35][C:33]([CH3:34])=[CH:32][CH:31]=1.C1C2C3C(=O)N(O)C(=O)C3C1C=C2.C1CCC(N=C=NC2CCCCC2)CC1>>[NH:25]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[C@H:26]([C:18]([NH:1][C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)=[O:20])[CH2:27][S:28][CH2:29][C:30]1[CH:36]=[CH:35][C:33]([CH3:34])=[CH:32][CH:31]=1参加物
5
実験手順
Using Boc-Phe-βAla-OH (prepared with 1.31 g Boc-Phe-βAla-OH.CHA), 1.02 g Boc-Cys(MBzl)-OH, 0.60 g HONB and 0.68 g DCC, the desired product was obtained in exactly the same manner as in Example 1-(XX), and was then crystallized with ether and collected by filtration.