化工社化工社 化学情報印刷レポート · 研究参考用
Methyl-9-trityloxy-nonanoate → Dodecanoic acid, 12-(triphenylmethoxy)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl-9-trityloxy-nonanoate | HCID 42624366 | — |
| 反応物 | Methyl 6-trityloxy-hexanoate | HCID 67198977 | — |
| 反応物 | Methyl-12-trityloxy-dodecanoate | HCID 67200799 | — |
| 生成物 | Dodecanoic acid, 12-(triphenylmethoxy)- | HCID 10790077 | — |
反応手順
Hydrolysis of the methyl ester of 15a, 15b, and 15c was carried out under basic conditions, followed by an acidic work up, during which the pH was maintained above 4 to prevent trityl deprotection. After recrystallization for solid product or flash chromatography for oil products, 6-trityloxyhexanoic acid 16a, 9-trityloxynonanoic acid 16b and 12-trityloxydodecanoic acid 16c were isolated, providing aliphatic side-chains that were ready to be coupled to 12 and 13.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623326B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-0c3f2de7ecae4ff483c3d51b7ba30cc8 |
| 出典メモ | uspto-grants-2014_01 |