Ammonia → 4-Bromo-alpha-methylbenzeneethanamine

HRID 467458

反応式

HRID 467458 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=O)[CH3:10])=[CH:4][CH:3]=1.[NH3:12].[H][H]>CO.[Ni]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH2:12])[CH3:10])=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 222AmmoniaHCID 7363321-(4-Bromophenyl)propan-2-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 2056684-Bromo-alpha-methylbenzeneethanamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒2 回HCID 887Methanol溶媒

実験手順

A mixture of 25.0 g (0.12 mol) 4-bromophenylacetone and 400 mL 7N ammonia in MeOH is charged with 1.20 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (15 psi) at r.t. over night. Again 0.6 g Raney nickel are added and the mixture is stirred again for 3.5 h. After complete reaction, the mixture is filtrated. The residue is washed with MeOH and the solvent of the filtrate is removed in vacuo. The crude product is used without further purification.

後処理

  1. customAfter complete reaction
  2. filtrationthe mixture is filtrated
  3. washThe residue is washed with MeOH
  4. customthe solvent of the filtrate is removed in vacuo
  5. customThe crude product is used without further purification

出典と根拠

ORDレコード
ord-80508a6c9110408290ac8e22285ba906
出典データセット
uspto-grants-2014_01
特許番号
US08623860B2

関連ノート

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