関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 4-Bromophenol | HCID 7808 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (Chloromethyl)cyclopropane | HCID 80013 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Bromo-4-(cyclopropylmethoxy)benzene | HCID 15625752 | — |
反応手順
5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried with MgSO4, filtered and the solvent is removed in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08623860B2 |
|---|
| 出典データセット | uspto-grants-2014_01 |
|---|
| ORD ID | ord-e2a0d5eb27f54a2c8c9fae9d97057072 |
|---|
| 出典メモ | uspto-grants-2014_01 |
|---|
