Triethylamine → HCID 14042135、化合物

HRID 467628ノート

反応式

HRID 467628 の反応式
[CH3:1][O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][CH:8]=[C:7](Br)[N:6]=1)=[O:4].[O:13]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14]1.C(N(CC)CC)C>CN(C=O)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C1(P(C2C=CC=CC=2)[C-]2C=CC=C2)C=CC=CC=1.[C-]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C1.[Fe+2]>[CH3:1][O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][CH:8]=[C:7]([C:15]2[CH:16]=[CH:17][O:13][CH:14]=2)[N:6]=1)=[O:4]

参加物

7

反応物 3

HCID 8471TriethylamineHCID 227251Methyl 3-Amino-6-bromopyrazine-2-carboxylateHCID 2734358Furan-3-boronic acid

生成物 1

HCID 14042135HCID 14042135、化合物

試薬・触媒・溶媒 3

HCID 167845palladium(II) acetate触媒HCID 635956Ferrocene-1,1'-bis-(diphenylphosphine)触媒HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

A mixture of palladium (II) acetate (145 mg, 0.65 mmol) and 1,1′-bis(diphenylphosphino)-ferrocene (493 mg, 0.86 mmol) in DMF (70 ml) was stirred at 50° C. for 15 minutes and cooled to r.t. The mixture was evacuated and vented with argon. 3-Amino-6-bromopyrazine-2-carboxylic acid methyl ester (5.0 g, 21.5 mmol), furan-3-yl-boronic acid (2.79 g, 23.7 mmol) and triethylamine (4.51 ml, 32.3 mmol) were added and the reaction mixture was stirred at 90° C. for 16 h. The solvent was evaporated and the product was obtained after purification by silica gel chromatography using a heptane/ethyl acetate gradient as yellow solid (2.92 g, 61.8%).

後処理

  1. temperaturecooled to r.t
  2. customThe mixture was evacuated
  3. stirringthe reaction mixture was stirred at 90° C. for 16 h
  4. customThe solvent was evaporated
  5. customthe product was obtained
  6. customafter purification by silica gel chromatography

出典と根拠

ORDレコード
ord-2a8146cd11674572a29f05d9300ef876
出典データセット
uspto-grants-2014_01
特許番号
US08623866B2

反応ノート

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