Potassium Hydroxide → 2-p-Chlorophenyl-5-phenylthio-4-thiazoleacetic acid

HRID 46770ノート

反応式

HRID 46770 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([S:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=2)=[CH:4][CH:3]=1.[OH-].[K+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([S:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 54037631Ethyl 2-p-chlorophenyl-5-phenylthio-4-thiazoleacetate

生成物 1

HCID 541246842-p-Chlorophenyl-5-phenylthio-4-thiazoleacetic acid収率 72.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 3.4 g of ethyl 2-p-chlorophenyl-5-phenylthio-4-thiazoleacetate in 100 ml of methanol was added 15 ml of 3 N aqueous potassium hydroxide. The mixture was stirred at room temperature for 3 hours. The solvent was distilled off under reduced pressure and water was added to the residue. The solution was acidified with hydrochloric acid. The white precipitated solid was filtered off, washed with water, dried and recrystallized from ethanol to give 2.3 g of the title compound, melting at 191°-193° C.

後処理

  1. distillationThe solvent was distilled off under reduced pressure and water
  2. additionwas added to the residue
  3. customThe white precipitated solid
  4. filtrationwas filtered off
  5. washwashed with water
  6. customdried
  7. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-7d4bf85428134dbaa864623b14535ef5
出典データセット
uspto-grants-1979_11
特許番号
US04175130

反応ノート

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