反応式
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[CH:21]=[N:20][CH:19]=[CH:18][C:14]=3[C:15]([OH:17])=O)=[O:11])[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.[NH2:29][CH:30]1[CH2:34][CH2:33][O:32][CH2:31]1>>[O:32]1[CH2:33][CH2:34][CH:30]([NH:29][C:15]([C:14]2[CH:18]=[CH:19][N:20]=[CH:21][C:13]=2[NH:12][C:10]([C:8]2[C:7]([NH:22][C:23]3[CH:28]=[N:27][CH:26]=[N:25][CH:24]=3)=[N:6][CH:5]=[C:4]([CH:1]3[CH2:3][CH2:2]3)[N:9]=2)=[O:11])=[O:17])[CH2:31]1参加物
3
実験手順
According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 3-aminotetrahydro-furan, providing the title compound as yellow solid (96%).
出典と根拠
- ORDレコード
- ord-a77e728767834f17a18b819d27297762
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08623866B2
関連ノート
読み込み中…