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Tetrahydrofurfurylamine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid {4-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-pyridin-3-yl}-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofurfurylamine | HCID 253298 | — |
| 反応物 | 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid | HCID 70098928 | — |
| 生成物 | 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid {4-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-pyridin-3-yl}-amide | HCID 58548374 | 77% |
反応手順
According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with (tetrahydrofuran-2-yl)methanamine, providing the title compound as yellow solid (77%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623866B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-f942ca0cd54a435bbd04ab545989cbff |
| 出典メモ | uspto-grants-2014_01 |