2-Propanol, 1-amino-2-methyl- → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-hydroxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide

HRID 467728

反応式

HRID 467728 の反応式
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[CH:21]=[N:20][CH:19]=[CH:18][C:14]=3[C:15]([OH:17])=O)=[O:11])[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.[NH2:29][CH2:30][C:31]([CH3:34])([OH:33])[CH3:32]>>[OH:33][C:31]([CH3:34])([CH3:32])[CH2:30][NH:29][C:15]([C:14]1[CH:18]=[CH:19][N:20]=[CH:21][C:13]=1[NH:12][C:10]([C:8]1[C:7]([NH:22][C:23]2[CH:24]=[N:25][CH:26]=[N:27][CH:28]=2)=[N:6][CH:5]=[C:4]([CH:1]2[CH2:3][CH2:2]2)[N:9]=1)=[O:11])=[O:17]

参加物

3

反応物 2

HCID 951022-Propanol, 1-amino-2-methyl-HCID 700989283-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid

生成物 1

HCID 585481616-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-hydroxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide収率 74%

実験手順

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 1-amino-2-methylpropan-2-ol, providing the title compound as yellow solid (74%).

出典と根拠

ORDレコード
ord-710c86833df94f7da0e38e7f9b6d63f3
出典データセット
uspto-grants-2014_01
特許番号
US08623866B2

関連ノート

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