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HRID 467729作成日：2026年10月25日

Oxetan-3-amine hydrochloride → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(oxetan-3-ylcarbamoyl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/467729

反応式

関与物質

役割名称HCID仕込み量
反応物Oxetan-3-amine hydrochlorideHCID 23062080—
反応物3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acidHCID 70098928—
生成物6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(oxetan-3-ylcarbamoyl)-pyridin-3-yl]-amideHCID 5854821758%

反応手順

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with oxetan-3-amine hydrochloride, providing the title compound as yellow solid (58%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08623866B2
出典データセットuspto-grants-2014_01
ORD IDord-bbba5cc4a98a4f4ea8f6cd009573e343
出典メモuspto-grants-2014_01