2-Methoxy-2-methylpropan-1-amine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-methoxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide

HRID 467732ノート

反応式

HRID 467732 の反応式
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[CH:21]=[N:20][CH:19]=[CH:18][C:14]=3[C:15]([OH:17])=O)=[O:11])[C:7]([NH:22][C:23]3[CH:24]=[N:25][CH:26]=[N:27][CH:28]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.[CH3:29][O:30][C:31]([CH3:35])([CH3:34])[CH2:32][NH2:33]>>[CH3:29][O:30][C:31]([CH3:35])([CH3:34])[CH2:32][NH:33][C:15]([C:14]1[CH:18]=[CH:19][N:20]=[CH:21][C:13]=1[NH:12][C:10]([C:8]1[C:7]([NH:22][C:23]2[CH:28]=[N:27][CH:26]=[N:25][CH:24]=2)=[N:6][CH:5]=[C:4]([CH:1]2[CH2:2][CH2:3]2)[N:9]=1)=[O:11])=[O:17]

参加物

3

反応物 2

HCID 117891412-Methoxy-2-methylpropan-1-amineHCID 700989283-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid

生成物 1

HCID 585483936-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid [4-(2-methoxy-2-methyl-propylcarbamoyl)-pyridin-3-yl]-amide収率 71%

実験手順

According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with 2-methoxy-2-methylpropan-1-amine, providing the title compound as yellow solid (71%).

出典と根拠

ORDレコード
ord-9ea9d7d233a44b46a7253bcb86f601df
出典データセット
uspto-grants-2014_01
特許番号
US08623866B2

反応ノート

読み込み中…