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N,1-dimethylpyrrolidin-3-amine → HCID 54762204、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,1-dimethylpyrrolidin-3-amine | HCID 2758520 | — |
| 反応物 | 4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid | HCID 70098073 | — |
| 生成物 | HCID 54762204 | HCID 54762204 | — |
反応手順
The product was obtained starting from 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid (25 mg, 66 μmol; example 236, step 3) and N,1-dimethyl-pyrrolidin-3-ylamine (10 mg, 85 μmol) according to the method described in example 64, step 6 after purification by preparative HPLC using an acetonitrile/water gradient as yellow solid (12 mg, 35%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623866B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-6b073f682a254b19a97e7987502b616e |
| 出典メモ | uspto-grants-2014_01 |