化工社化工社 化学情報印刷レポート · 研究参考用
Phenylmethyl 4-nitrobenzoate → Benzyl p-aminobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylmethyl 4-nitrobenzoate | HCID 84647 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Benzyl p-aminobenzoate | HCID 98488 | 93.4% |
反応手順
20.6 g of the benzyl 4-nitrobenzoate are dissolved in 350 mL dioxane and this solution is combined with 6.9 g (49.9 mmol, 0.61 eq) Raney nickel. The mixture is hydrogenated at 5 bar H2 pressure for 16 h with stirring. The catalyst is filtered off and all the volatile constituents are eliminated in vacuo. 17 g benzyl 4-aminobenzoate are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623887B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-089e658d436f4ff495a9757f8aaf70de |
| 出典メモ | uspto-grants-2014_01 |