2-Oxobutanoic Acid → ethyl acetoacetate, sodium salt

HRID 467825

反応式

HRID 467825 の反応式
[O:1]=[C:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4].O.[C:9]1(C)C=CC(S(O)(=O)=O)=C[CH:10]=1>C(O)C>[CH2:9]([O:4][C:3](=[O:5])[C:2](=[O:1])[CH2:6][CH3:7])[CH3:10]

参加物

4

反応物 2

HCID 582-Oxobutanoic AcidHCID 521998p-Toluenesulfonic acid monohydrate

生成物 1

HCID 85195ethyl acetoacetate, sodium salt収率 16,662.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Oxo-butyric acid (10.0 g, 97.2 mmol) was dissolved in ethanol (100 mL) and p-toluene sulfonic acid mono hydrate (0.1 g) was added. The reaction mixture was heated to reflux for 48 h. After cooling the reaction mixture to room temperature, the ethanol was removed under reduced pressure to give 11.4 g of 2-oxo-butyric acid ethyl ester.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 48 h
  3. customthe ethanol was removed under reduced pressure

出典と根拠

ORDレコード
ord-c64981ff2cb44d57a8bca56549480017
出典データセット
uspto-grants-2014_01
特許番号
US08623890B2

関連ノート

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