N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide → N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide

HRID 467963ノート

反応式

HRID 467963 の反応式
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]([F:30])([F:29])[F:28])[CH:21]=2)[C:8]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]3[CH:18]=2)=[O:9])[CH2:3][CH2:2]1>[C].[Pd].CO>[O:1]1[CH2:6][CH2:5][CH:4]([N:7]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]([F:28])([F:29])[F:30])[CH:21]=2)[C:8]([C:10]2[N:11]=[C:12]3[CH2:17][CH2:16][CH2:15][CH2:14][N:13]3[CH:18]=2)=[O:9])[CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 58049370N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide

生成物 1

HCID 46916730N-(Tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide収率 95.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

A mixture of N-(tetrahydro-2H-pyran-4-yl)-N-[3-(trifluoromethoxy)benzyl]imidazo[1,2-a]pyridine-2-carboxamide (50 mg), 10% palladium-carbon (50 mg) and methanol (15 mL) was stirred in a nitrogen atmosphere for 2 hours at room temperature. The insoluble matter was filtered off and methanol was distilled off under reduced pressure to give the titled compound (48 mg).

後処理

  1. filtrationThe insoluble matter was filtered off
  2. distillationmethanol was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-d15a8106b1404230a679aa89ae608dfc
出典データセット
uspto-grants-2014_01
特許番号
US08623898B2

反応ノート

読み込み中…