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Piperidine → 2,6-Dimethyl-6-piperidino-4-hepten-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 2-Methyl-3-buten-2-ol | HCID 8257 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 1-Bromo-2-methyl-1-propene | HCID 98560 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 生成物 | 2,6-Dimethyl-6-piperidino-4-hepten-2-ol | HCID 54023182 | 31% |
反応手順
A mixture of 10 mmoles 2-methyl-1-bromo-1-propene, 12.5 mmoles 2-methyl-3-buten-2-ol, 30 mmoles piperidine, 0.20 mmole palladium acetate and 0.40 mmole triphenylphosphine was reacted at 100° C. There was produced 61% of a mixture of nonadienols, 31% 2,6-dimethyl-6-piperidino-4-hepten-2-ol and 6% of what is believed to be 2,6-dimethyl-4-piperidino-5-hepten-2-ol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04175187 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-2a8da2881cb74fe29c07cbad6f53654a |
| 出典メモ | uspto-grants-1979_11 |