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(S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol → Quinidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol | HCID 5953 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Fluoreneone | HCID 22281833 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Quinidinone | HCID 84497 | — |
反応手順
A solution of fluorenone ketyl was prepared by mixing 9 g. of fluorenone and 6.5 g. of sodium in anhydrous toluene. To this solution was added a hot solution of 37 g. of anhydrous quinidine base in 150 ml. of anhydrous toluene. After 15 minutes at reflux, the reaction was complete. After extraction and neutralization treatments as in Example I, 36 g. of pure quinidinone (TLC) was obtained (97% of theory).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04175192 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-2e349f16a0ab4c7baaf37321e4e4dae6 |
| 出典メモ | uspto-grants-1979_11 |