関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-tert-Butyl-1H-indole | HCID 594166 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-(tert-Butyl)indoline | HCID 4642643 | 116.5% |
反応手順
To a solution of 2-tert-butyl-1H-indole (10 g, 48 mmol) in AcOH (40 mL) was added NaBH4 at 10° C. The mixture was stirred for 20 minutes at 10° C. before being treated dropwise with H2O under ice cooling. The mixture was extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4, filtered, and concentrated under vacuum to give 2-tert-butylindoline (9.8 g), which was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08623905B2 |
|---|
| 出典データセット | uspto-grants-2014_01 |
|---|
| ORD ID | ord-ef6a4cefa9ac48f09e6df065def70b07 |
|---|
| 出典メモ | uspto-grants-2014_01 |
|---|
