1-Propanol, 3-[[2-nitro-4-(trifluoromethyl)phenyl]amino]- → 3-{[2-Amino-4-(trifluoromethyl)phenyl]amino}-1-propanol

HRID 46842

反応式

HRID 46842 の反応式
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH2:15][CH2:16][CH2:17][OH:18])([O-])=O.[H][H]>[Ni].CO>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]([F:12])([F:13])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH2:15][CH2:16][CH2:17][OH:18]

参加物

5

反応物 2

HCID 28475091-Propanol, 3-[[2-nitro-4-(trifluoromethyl)phenyl]amino]-HCID 178418361HCID 178418361、化合物

生成物 1

HCID 203855523-{[2-Amino-4-(trifluoromethyl)phenyl]amino}-1-propanol収率 100%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A mixture of 141 parts of 3-{[2-nitro-4-(trifluoromethyl)phenyl]amino}-1-propanol and 1200 parts of methanol is hydrogenated at normal pressure and at room temperature with 15 parts of Raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is crystallized from 2,2'-oxybispropane, yielding 110 parts (100%) of 3-{[2-amino-4-(trifluoromethyl)phenyl]amino}-1-propanol.

後処理

  1. filtrationthe catalyst is filtered off
  2. customthe filtrate is evaporated
  3. customThe residue is crystallized from 2,2'-oxybispropane

出典と根拠

ORDレコード
ord-f6796aea8dea42f192e2fdb2af1f3337
出典データセット
uspto-grants-1979_11
特許番号
US04175129

関連ノート

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