1-(2,3-Dihydro-1H-inden-5-yl)ethan-1-one → 2,3-dihydro-1H-indene-5-carboxylic acid

HRID 468498

反応式

HRID 468498 の反応式
Cl[O-].[Na+].[CH2:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13](=[O:15])C)[CH:11]=2)[CH2:6][CH2:5]1.C([O-])(O)=[O:17].[Na+]>>[CH2:6]1[C:7]2[C:12](=[CH:11][C:10]([C:13]([OH:15])=[O:17])=[CH:9][CH:8]=2)[CH2:4][CH2:5]1

参加物

4

反応物 3

HCID 2339761-(2,3-Dihydro-1H-inden-5-yl)ethan-1-oneHCID 516892Sodium BicarbonateHCID 23665760Sodium Hypochlorite

生成物 1

HCID 2328412,3-dihydro-1H-indene-5-carboxylic acid収率 99%

反応条件

温度
55 °C

実験手順

To a stirred aqueous sodium hypochlorite solution (2230 ml, 1.80 mmol, 6%) at 55° C. was added 1-(2,3-dihydro-1H-inden-6-yl)ethanone (120.0 g, 0.75 mol) and the mixture was stirred at 55° C. for 2 h. After cooling to room temperature, saturated NaHCO3 solution was added until the solution became clear. The produced precipitate was filtered, washed several times with water and dried to afford the desired product (120.0 g, 99%). 1H NMR (CDCl3, 300 MHz) δ 2.07-2.17 (m, 2H), 2.96 (t, J=7.5 Hz, 4H), 7.30 (d, J=7.8, 1H,), 7.91 (d, J=7.8, 1H), 7.96 (s, 1H).

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationThe produced precipitate was filtered
  3. washwashed several times with water
  4. customdried

出典と根拠

ORDレコード
ord-e28cff40336a49ac84d510de84005e56
出典データセット
uspto-grants-2014_01
特許番号
US08623905B2

関連ノート

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