3-Amino-1-propanol → 3-[(2-Chloro-6-nitrophenyl)amino]-1-propanol

HRID 46853

反応式

HRID 46853 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1Cl.[NH2:12][CH2:13][CH2:14][CH2:15][OH:16]>C(O)CCC>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1[NH:12][CH2:13][CH2:14][CH2:15][OH:16]

参加物

4

反応物 2

HCID 90863-Amino-1-propanolHCID 185552,3-Dichloronitrobenzene

生成物 1

HCID 203855663-[(2-Chloro-6-nitrophenyl)amino]-1-propanol

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A mixture of 100 parts of 1,2-dichloro-3-nitrobenzene, 95 parts of 3-amino-1-propanol and 200 parts of butanol is stirred and refluxed overnight. The reaction mixture is cooled and evaporated. The residue is taken up in water and the product is extracted with methylbenzene. The extract is washed with water, dried, filtered and evaporated, yielding 115 parts of 3-[(2-chloro-6-nitrophenyl)amino]-1-propanol as a residue.

後処理

  1. temperaturerefluxed overnight
  2. temperatureThe reaction mixture is cooled
  3. customevaporated
  4. extractionthe product is extracted with methylbenzene
  5. washThe extract is washed with water
  6. customdried
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-3cf7f60be5d04e27a25f57e8e5833753
出典データセット
uspto-grants-1979_11
特許番号
US04175129

関連ノート

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