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Ammonium Hydroxide → 2-Amino-4-chloropyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 生成物 | 2-Amino-4-chloropyrimidine | HCID 223332 | — |
| 生成物 | 2-Chloro-4-aminopyrimidine | HCID 345752 | — |
反応手順
To 2,4-Dichloropyrimidine (1.0 g, 6.7 mmol) was added 28% w/v ammonium hydroxide solution (20 mL). The mixture was stirred overnight at ambient temperature then concentrated in vacuo. The residue was dry loaded and purified by FCC eluting with 2-10% EtOH in CHCl3 to afford 2-amino-4-chloropyrimidine and 2-chloro-4-aminopyrimidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623859B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-20a8d0fd8cdf4fd5ae501cd05436ce51 |
| 出典メモ | uspto-grants-2014_01 |