化工社化工社 化学情報印刷レポート · 研究参考用
1-[(1-Methylpiperidin-3-yl)methyl]piperazine → Ammonia
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-[(1-Methylpiperidin-3-yl)methyl]piperazine | HCID 2736940 | — |
| 反応物 | Trimethylaluminum | HCID 16682925 | — |
| 反応物 | Methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate | HCID 67217606 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | Ammonia | HCID 222 | — |
| 生成物 | 4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide | HCID 46176070 | — |
反応手順
The title compound was prepared according to general procedure AT using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-oxadiazole-2-carboxylate (30 mg, 0.08 mmol), 1-[(1-methylpiperidin-3-yl)methyl]piperazine (31 mg, 0.16 mmol) and trimethylaluminium (2 M in toluene, 0.08 mL) in DCE (5 mL). The crude product was purified using FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623859B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-5f575b8bf1424c28b0151939205d7d72 |
| 出典メモ | uspto-grants-2014_01 |