1,2-Dichloroethane → N-{[5-({4-[(2-Aminopyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide

反応式

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH3:28])[CH2:14][C:15]2[O:16][C:17]([C:20]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[O:21])=[N:18][N:19]=2)(=[O:12])=[O:11])=[C:5]([CH3:29])[CH:4]=1.[NH2:30][C:31]1[C:36]([CH:37]=O)=[CH:35][CH:34]=[CH:33][N:32]=1.ClCCCl>>[NH2:30][C:31]1[C:36]([CH2:37][N:25]2[CH2:24][CH2:23][N:22]([C:20]([C:17]3[O:16][C:15]([CH2:14][N:13]([CH3:28])[S:10]([C:6]4[C:7]([CH3:9])=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=4[CH3:29])(=[O:11])=[O:12])=[N:19][N:18]=3)=[O:21])[CH2:27][CH2:26]2)=[CH:35][CH:34]=[CH:33][N:32]=1

参加物

反応物 3

HCID 111,2-Dichloroethane

HCID 7376333-Pyridinecarboxaldehyde, 2-amino-

HCID 583933044-Methoxy-N,2,6-trimethyl-N-{[5-(piperazin-1-ylcarbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide

生成物 1

HCID 46176324N-{[5-({4-[(2-Aminopyridin-3-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-oxadiazol-2-yl]methyl}-4-methoxy-N,2,6-trimethylbenzenesulfonamide

実験手順

The title compound was prepared according to general procedure CD using 4-methoxy-N,2,6-trimethyl-N-{[5-(piperazin-1-ylcarbonyl)-1,3,4-oxadiazol-2-yl]methyl}benzenesulfonamide (42 mg, 0.10 mmol), 2-aminopyridine-3-carbaldehyde (15 mg, 0.12 mmol), STAB (42 mg, 0.2 mmol) DCE (0.8 mL) and a few 4 Å molecular sieves. The crude product was purified using prep method D.