化工社化工社 化学情報印刷レポート · 研究参考用
1-((1-Methyl-4-piperidinyl)methyl)piperazine → Ammonia
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-((1-Methyl-4-piperidinyl)methyl)piperazine | HCID 2736942 | — |
| 反応物 | Trimethylaluminum | HCID 16682925 | — |
| 反応物 | ethyl 3-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,2,4-oxadiazole-5-carboxylate | HCID 58393317 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | Ammonia | HCID 222 | — |
| 生成物 | N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,2,4-oxadiazol-3-yl]methyl}benzenesulfonamide | HCID 46175637 | — |
反応手順
The title compound was prepared according to general procedure AT using ethyl 3-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,2,4-oxadiazole-5-carboxylate (30 mg, 0.07 mmol), 1-[(1-methylpiperidin-4-yl)methyl]piperazine (31 mg, 0.14 mmol) and trimethylaluminium (2 M in toluene, 0.07 mL) in DCE (5 mL). A portion of the crude product was purified using prep method C, then FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623859B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-4471b3c823694861ac067baaca3fabaa |
| 出典メモ | uspto-grants-2014_01 |