1-(3-Pyrrolidinopropyl)Piperazine → 4-Methoxy-N,2,6-trimethyl-N-[(3-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide

HRID 469125

反応式

HRID 469125 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][N:19]=[C:18]([C:21](OCC)=[O:22])[N:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:26])[CH:4]=1.[N:27]1([CH2:32][CH2:33][CH2:34][N:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH2:31][CH2:30][CH2:29][CH2:28]1.C[Al](C)C>ClCCCl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH3:26])[C:6]([S:10]([N:13]([CH3:14])[CH2:15][C:16]2[O:20][N:19]=[C:18]([C:21]([N:38]3[CH2:37][CH2:36][N:35]([CH2:34][CH2:33][CH2:32][N:27]4[CH2:28][CH2:29][CH2:30][CH2:31]4)[CH2:40][CH2:39]3)=[O:22])[N:17]=2)(=[O:12])=[O:11])=[C:7]([CH3:9])[CH:8]=1

参加物

5

反応物 3

HCID 27372521-(3-Pyrrolidinopropyl)PiperazineHCID 16682925TrimethylaluminumHCID 58393139Ethyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,2,4-oxadiazole-3-carboxylate

生成物 1

HCID 583932824-Methoxy-N,2,6-trimethyl-N-[(3-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

The title compound was prepared according to general procedure AT using ethyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,2,4-oxadiazole-3-carboxylate (27 mg, 0.07 mmol), 1-[3-(pyrrolidin-1-yl)propyl]piperazine (40 mg, 0.20 mmol) and trimethylaluminium (2 M in toluene, 0.08 mL) in DCE (2 mL). A portion of the crude product was purified using prep method D.

後処理

  1. customA portion of the crude product was purified

出典と根拠

ORDレコード
ord-3deb2db89e5c47fc9b9272b5b3a67b1c
出典データセット
uspto-grants-2014_01
特許番号
US08623859B2

関連ノート

読み込み中…