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1-((1-Methyl-4-piperidinyl)methyl)piperazine → 4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-thiadiazol-2-yl]methyl}benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-((1-Methyl-4-piperidinyl)methyl)piperazine | HCID 2736942 | — |
| 反応物 | Trimethylaluminum | HCID 16682925 | — |
| 反応物 | Methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-thiadiazole-2-carboxylate | HCID 58392977 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-thiadiazol-2-yl]methyl}benzenesulfonamide | HCID 58392987 | — |
反応手順
The title compound was prepared according to general procedure BK using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-thiadiazole-2-carboxylate (100 mg, 0.26 mmol), 1-(1-methyl-piperidin-4-ylmethyl)-piperazine (61 mg, 0.31 mmol), trimethylaluminium (2 M in toluene, 0.28 mL) and THF (10 mL).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623859B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-a35e4764f7194401a85b086089a05653 |
| 出典メモ | uspto-grants-2014_01 |