化工社化工社 化学情報印刷レポート · 研究参考用
1-(1-Methyl-4-piperidinyl)piperazine → Ammonia
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(1-Methyl-4-piperidinyl)piperazine | HCID 566324 | — |
| 反応物 | Trimethylaluminum | HCID 16682925 | — |
| 反応物 | ethyl 5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3,4-thiadiazole-2-carboxylate | HCID 58393201 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | Ammonia | HCID 222 | — |
| 生成物 | N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(1-methylpiperidin-4-yl)piperazin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide | HCID 58393376 | — |
反応手順
The title compound was prepared according to general procedure AT using ethyl 5-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3,4-thiadiazole-2-carboxylate (30 mg, 0.07 mmol), 1-(1-methylpiperidin-4-yl)piperazine (26 mg, 0.14 mmol) and trimethylaluminium (2 M in toluene, 0.07 mL) in DCE (5 mL). The crude product was purified using FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623859B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-79758d6df2224fe7b3180851d14d23a5 |
| 出典メモ | uspto-grants-2014_01 |