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Methanethiol → 3-(4-Methoxybenzylmercapto)-2-(methylthio)propanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanethiol | HCID 878 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Bromo-3-(4-methoxybenzylmercapto)propanoic acid | HCID 20385290 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(4-Methoxybenzylmercapto)-2-(methylthio)propanoic acid | HCID 54057018 | — |
反応手順
A solution of 2-bromo-3-(4-methoxybenzylmercapto) propanoic acid (15 g.), methylmercaptan (3 g.) and sodium hydroxide (4.6 g.) in 95% ethanol (25 ml.) is refluxed for twelve hours. The sodium bromide is filtered off and the filtrate is concentrated to dryness in vacuo. The residue is dissolved in water, acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness to yield 3-(4-methoxybenzylmercapto)-2-(methylthio)propanoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04175199 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-8ad601f13c6f431c95ae6615f781c44e |
| 出典メモ | uspto-grants-1979_11 |