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4,6-Dichloro-2-(methylthio)pyrimidine → Ethyl 6-(6-chloro-2-(methylthio)pyrimidin-4-ylamino)nicotinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloro-2-(methylthio)pyrimidine | HCID 80531 | — |
| 反応物 | Ethyl 6-Aminonicotinate | HCID 235927 | — |
| 反応物 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Ethyl 6-(6-chloro-2-(methylthio)pyrimidin-4-ylamino)nicotinate | HCID 86679315 | — |
反応手順
A mixture of 4,6-dichloro-2-(methylthio)pyrimidine (1 g), ethyl 6-aminonicotinate (0.85 g) and NaHMDS (10.3 mL, 1M in THF) in THF (50 mL) was stirred at room temperature for 16 hours. The mixture was diluted with water and extracted with EtOAc (2×150 mL). The organic layers were combined, washed with brine (50 mL), dried over MgSO4 and concentrated to give ethyl 6-(6-chloro-2-(methylthio)pyrimidin-4-ylamino)nicotinate which was used as was.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08629150B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-93d8f17e7b9343648392cf65a432290e |
| 出典メモ | uspto-grants-2014_01 |