Aluminum(III) Chloride → HCID 58181206、化合物

HRID 469296

反応式

HRID 469296 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8](Cl)=[O:9])[CH:3]=1.[Cl-].[Cl-].[Cl-].[Al+3].[CH3:15][C:16]1[C:21]2[NH:22][C:23](=[O:25])[O:24][C:20]=2[CH:19]=[CH:18][CH:17]=1>>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([C:18]2[CH:17]=[C:16]([CH3:15])[C:21]3[NH:22][C:23](=[O:25])[O:24][C:20]=3[CH:19]=2)=[O:9])[CH:3]=1

参加物

4

反応物 3

HCID 6451240Aluminum(III) ChlorideHCID 127093364-Methyl-3H-benzooxazol-2-oneHCID 184220986-Chloropyrimidine-4-carbonyl chloride

生成物 1

HCID 58181206HCID 58181206、化合物

反応条件

温度
130 °C

実験手順

A well stirred mixture of 2.34 g (13.2 mmol) 6-chloropyrimidine-4-carboxylic acid chloride, 8.00 g (60.0 mmol) aluminium trichloride and 1.79 g (12.0 mmol) 4-methyl-3H-benzoxazol-2-one was heated to 130° C. for 1.5 h. After cooling to RT the mixture was decomposed with ice water, then extracted with ethyl acetate, the organic phase was dried on sodium sulphate and evaporated down i. vac. The crude product left as a solid was triturated with diethyl ether, suction filtered and dried in the air.

後処理

  1. temperatureAfter cooling to RT the mixture
  2. extractionextracted with ethyl acetate
  3. customthe organic phase was dried on sodium sulphate
  4. customevaporated down i
  5. waitThe crude product left as a solid
  6. customwas triturated with diethyl ether, suction
  7. filtrationfiltered
  8. customdried in the air

出典と根拠

ORDレコード
ord-c961173ac0b74a0d908d78f18e71632f
出典データセット
uspto-grants-2014_01
特許番号
US08629137B2

関連ノート

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