Aluminum(III) Chloride → 6-(5-bromo-pyridin-3-carbonyl)-4-methyl-3H-benzoxazol-2-one

HRID 469326ノート

反応式

HRID 469326 の反応式
Cl.[Br:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:11]=1)[C:8](Cl)=[O:9].[CH3:12][C:13]1[C:18]2[NH:19][C:20](=[O:22])[O:21][C:17]=2[CH:16]=[CH:15][CH:14]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[Br:2][C:3]1[CH:11]=[C:7]([C:8]([C:15]2[CH:14]=[C:13]([CH3:12])[C:18]3[NH:19][C:20](=[O:22])[O:21][C:17]=3[CH:16]=2)=[O:9])[CH:6]=[N:5][CH:4]=1

参加物

4

反応物 3

HCID 6451240Aluminum(III) ChlorideHCID 127093364-Methyl-3H-benzooxazol-2-oneHCID 189717365-Bromo-nicotinic acid chloride hydrochloride

生成物 1

HCID 581811166-(5-bromo-pyridin-3-carbonyl)-4-methyl-3H-benzoxazol-2-one

実験手順

2.57 g (10.0 mmol) 5-bromo-nicotinic acid chloride hydrochloride, 1.49 g (10.0 mmol) 4-methyl-3H-benzoxazol-2-one and 5.33 g (40.0 mmol) aluminium trichloride were heated to 125° C. with stirring for 1.5 h. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered, washed with water and dried i. vac.

後処理

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customdried i

出典と根拠

ORDレコード
ord-708df34646e244ee8b57dd9f0e41748c
出典データセット
uspto-grants-2014_01
特許番号
US08629137B2

反応ノート

読み込み中…