3-Hydroxy-2-naphthoic acid → 2-Naphthalenecarboxylic acid, 4-chloro-3-hydroxy-

HRID 46947

反応式

HRID 46947 の反応式
[Cl:1][O-].[Na+].[OH:4][C:5]1[C:14]([C:15]([OH:17])=[O:16])=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1>Cl>[Cl:1][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:13]=[C:14]([C:15]([OH:17])=[O:16])[C:5]=1[OH:4]

参加物

4

反応物 2

HCID 71043-Hydroxy-2-naphthoic acidHCID 23665760Sodium Hypochlorite2 回

生成物 1

HCID 925992-Naphthalenecarboxylic acid, 4-chloro-3-hydroxy-収率 91.8%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

The chilled sodium hypochlorite solution is added to the chilled solution of 2-hydroxy-3-naphthoic acid, keeping the temperature below 10° C. When the addition of sodium hypochlorite is completed, the reaction mixture is held at about 10° C. for 2 hours and then heated to the boil. To this solution is then added 250 ml of 14.1% hydrochloric acid. The resulting slurry of deep yellow solid material is heated to the boil and then cooled to ambient temperature. The slurry is filtered, washed with 2 liters of water and dried to constant weight. There is obtained 52.6 grams of 1-chloro-2-hydroxy-3-naphthoic acid (purity 97.2% by HPLC) representing a yield of 91.8% of theoretical.

後処理

  1. customthe temperature below 10° C
  2. temperatureheated to the boil
  3. temperatureThe resulting slurry of deep yellow solid material is heated to the boil
  4. filtrationThe slurry is filtered
  5. washwashed with 2 liters of water
  6. customdried to constant weight

出典と根拠

ORDレコード
ord-e7a3069927da47618005dcc98e0799b6
出典データセット
uspto-grants-1979_11
特許番号
US04175208

関連ノート

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