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4-Chlorophenylacetyl chloride → 2-(4-chlorophenyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorophenylacetyl chloride | HCID 90692 | — |
| 反応物 | 2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one | HCID 67161111 | — |
| 生成物 | 2-(4-chlorophenyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide | HCID 53237066 | 83.8% |
反応手順
The product of Example 11B (41 mg) and 2-(4-chlorophenyl)acetyl chloride (0.030 mL, 0.20 mmol) were treated using a method similar to that described in Example 1C to give the title compound (57 mg, 0.15 mmol) as a white solid. 1H NMR (300 MHz, DMSO-d6) δ 11.90 (s, 1H), 8.42 (dd, 1H), 8.19-7.97 (m, 3H), 7.41 (dd, J=3.3 Hz, 4H), 3.74 (s, 2H); MS (DCI) M/Z 399.2 (M+NH4)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08629143B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-b9d8c8eda75f47c4a8cce4820e5b503a |
| 出典メモ | uspto-grants-2014_01 |