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2-(5-chlorothiophen-2-yl)acetic Acid → 2-(5-chloro-2-thienyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(5-chlorothiophen-2-yl)acetic Acid | HCID 4426716 | — |
| 反応物 | 2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one | HCID 67161111 | — |
| 生成物 | 2-(5-chloro-2-thienyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide | HCID 67160460 | — |
反応手順
The product of Example 11B and 2-(5-chlorothiophen-2-yl)acetic acid were treated using a method similar to that described in Example 5 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.96-11.98 (bs, 1H), 8.43 (d, J=8.4 Hz, 1H), 8.11-8.17 (m, 1H), 7.97-8.10 (m, 2H), 7.01 (d, J=3.8 Hz, 1H), 6.93 (d, J=3.8 Hz, 1H), 3.96 (d, J=0.8 Hz, 2H); MS (ESI) m/z 388 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08629143B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-504f916a9ec141e880d3ab927e747ed1 |
| 出典メモ | uspto-grants-2014_01 |