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2-Pyridineacetic acid, hydrochloride (1:1) → N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(pyridin-2-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Pyridineacetic acid, hydrochloride (1:1) | HCID 85317 | — |
| 反応物 | 2-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one | HCID 67161367 | — |
| 生成物 | N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(pyridin-2-yl)acetamide | HCID 53239327 | — |
反応手順
The product of Example 86A and 2-(pyridin-2-yl)acetic acid hydrochloride were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.71-8.73 (m, 1H), 8.41-8.43 (m, 1H), 8.22 (td, J=7.8, 1.7 Hz, 1H), 7.94-8.06 (m, 2H), 7.82 (d, J=7.9 Hz, 1H), 7.73-7.75 (m, 1H), 7.69 (d, J=6.8 Hz, 1H), 7.59-7.67 (m, 4H); MS (APCI+) M/Z 391 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08629143B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-13632f3f9b4c4a66b533371a680315d1 |
| 出典メモ | uspto-grants-2014_01 |