2-Bromo-6-hydrazinopyridine → tert-Butyl 3-(2-(6-bromopyridin-2-yl)hydrazono)-9-azabicyclo[3.3.1]nonane-9-carboxylate
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][NH2:9])[N:3]=1.O=[C:11]1[CH2:18][CH:17]2[N:19]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH:13]([CH2:14][CH2:15][CH2:16]2)[CH2:12]1>CCO>[Br:1][C:2]1[N:3]=[C:4]([NH:8][N:9]=[C:11]2[CH2:18][CH:17]3[N:19]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH:13]([CH2:14][CH2:15][CH2:16]3)[CH2:12]2)[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
2-Bromo-6-hydrazinylpyridine (393 mg, 2.09 mmol) and tert-butyl 3-oxo-9-azabicyclo[3.3.1]nonane-9-carboxylate (500 mg, 2.09 mmol) were heated at reflux in EtOH (5 mL) for 16 h and the mixture concentrated to provide the title compound (855 mg, 100%) as a yellow solid: ESI MS m/z 409 [M+H]+.