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Carbon tetrabromide → tert-Butyl 3-bromopropionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon tetrabromide | HCID 11205 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | tert-Butyl 3-hydroxypropanoate | HCID 16218743 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | tert-Butyl 3-bromopropionate | HCID 256128 | — |
反応手順
3-Hydroxy-propionic acid tert-butyl ester is dissolved in acetonitrile and carbon tetrabromide and triphenylphosphine is added. The mixture is stirred at room temperature overnight. After this time the mixture is concentrated in vacuo. The gummy solid is triturated with hexanes and the liquid decanted, passed through pad of silica to remove any triphenylphosphine oxide, and concentrated in vacuo. 1H NMR (400 MHz, CHLOROFORM-d) ppm 1.3 (9H, s), 2.06-2.27 (2H, m), 4.07-4.25 (2H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08629157B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-dcb257f0551e46a2852671ecd9f8e2c7 |
| 出典メモ | uspto-grants-2014_01 |