(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 5-Cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-N-(3-trifluoromethyl-[1,2,4]oxadiazol-5-ylmethyl)-nicotinamide
反応式
[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([OH:14])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:22][C:23]([F:32])([F:31])[C:24]1[N:28]=[C:27]([CH2:29][NH2:30])[O:26][N:25]=1>>[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([NH:30][CH2:29][C:27]2[O:26][N:25]=[C:24]([C:23]([F:32])([F:31])[F:22])[N:28]=2)=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
3
実験手順
The title compound was synthesized in analogy to Example 1b using 5-cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid (Example 4b) and C-(3-trifluoromethyl-1,2,4-oxadiazol-5-yl)-methylamine (CAN 944905-93-5) as starting materials; MS (ESI) 453.1 (M+H)+.
出典と根拠
- ORDレコード
- ord-44d315b3df544fbdbc28a2f663afce85
- 出典データセット
- uspto-grants-2014_01
- DOI