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Hexahydrophthalic anhydride, cis- → HCID 20384700、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexahydrophthalic anhydride, cis- | HCID 641660 | — |
| 反応物 | 4-Amino-3-fluorobenzonitrile | HCID 2756431 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 20384700 | HCID 20384700 | — |
反応手順
To a solution of 5 parts of cis-1,2-cyclohexane dicarboxylic anhydride in 75 parts of glacial acetic acid was added 4.8 parts of 4-amino-3-fluorobenzonitrile in one portion. The mixture was refluxed for 4 hours, poured over 200 parts of ice and filtered. The crude crystalline product was recrystallized from methanol to yield 4.4 parts of beige 4-(1,3-dioxo-2,3,3a,4,5,6,7,7a-octahydro-1H-isoindol-2-yl)-3-fluorobenzonitrile melting 120°-123°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04175948 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-695eb91dec3049ec9dfb2355e89b357a |
| 出典メモ | uspto-grants-1979_11 |