HCID 59784811、化合物 → HCID 67058658、化合物

HRID 470330ノート

反応式

HRID 470330 の反応式
[NH2:1][C:2]1[C:6]([C:7]([OH:9])=O)=[CH:5][N:4]([C:10]2[N:19]=[CH:18][C:17]3[CH2:16][CH2:15][C:14]4[CH:20]=[C:21]([O:24][CH3:25])[CH:22]=[CH:23][C:13]=4[C:12]=3[N:11]=2)[N:3]=1.BrC1C=CC2[NH:31]C(C(Cl)(Cl)Cl)=NC=2C=1>CC(N(C)C)=O>[NH2:1][C:2]1[C:6]([C:7]([NH2:31])=[O:9])=[CH:5][N:4]([C:10]2[N:19]=[CH:18][C:17]3[CH2:16][CH2:15][C:14]4[CH:20]=[C:21]([O:24][CH3:25])[CH:22]=[CH:23][C:13]=4[C:12]=3[N:11]=2)[N:3]=1

参加物

4

反応物 2

HCID 59784811HCID 59784811、化合物HCID 178478477HCID 178478477、化合物

生成物 1

HCID 67058658HCID 67058658、化合物

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

A solution of benzimidazole-2-aldehyde 1 (0.5 mmol) and diamine 2 (0.5 mmol) in dimethylacetamide (4 mL) was stirred at 100° C. for 12 h. Solvent was evaporated and residue was purified by preparative HPLC to give benzimidazole derivative 3. 1H NMR (300 MHz, MeOH-d4): δ 2.52 (s, 3H), 2.85 (brs, 4H), 3.25 (brs, 4H), 7.05-7.15 (m, 2H), 7.25-7.35 (s overlapped with m, 2H), 7.60-7.75 (m, 4H); LCMS m/z 333 (M+H+), ELSD 99%.

後処理

  1. customSolvent was evaporated
  2. customresidue was purified by preparative HPLC

出典と根拠

ORDレコード
ord-c98c185a80ea457fa71d613308d87c57
出典データセット
uspto-grants-2014_01
特許番号
US08629147B2

反応ノート

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