Ethyl cyanoacetate → HCID 178509384、化合物
反応式
[NH2:1][C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:10]([CH2:12][C:13](OCC)=[O:14])#[N:11].N1CCCCC1>C(O)C>[OH:14][C:13]1[C:12]([C:10]#[N:11])=[CH:4][C:3]2[C:2](=[N:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1参加物
5
実験手順
A mixture of 2-aminonicotinaldehyde (2.44 g., 0.02 m), ethyl α-cyanoacetate (4.52 g., 0.04 m.), absolute ethanol (50 ml.) and piperidine (0.5 ml) is stirred under reflux. After 1 hour, the solution is cooled to 0°-4° C. The yellow solid is filtered and dried to yield 2.5 g. (73%) of 2-hydroxy-3-cyano-1,8-naphthyridines, m.p. 300° C.
後処理
- temperatureunder reflux
- temperaturethe solution is cooled to 0°-4° C
- filtrationThe yellow solid is filtered
- customdried
- customto yield 2.5 g
出典と根拠
- ORDレコード
- ord-2e9252f1b37d4a8f95e6b4a6feb9158b
- 出典データセット
- uspto-grants-1979_11
- 特許番号
- US04176183
反応ノート
読み込み中…