5,6-Dimethoxyindolin-2-one → HCID 178486553、化合物
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[CH2:6]2.[CH:15]([O-])([O-])[O:16]CC>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[C:6]2=[CH:15][OH:16]参加物
3
実験手順
As illustrated above in Scheme (A), the intermediate, 5,6-dimethoxy oxindole (I) is reacted with ethyl ortho formate (II) to provide 5,6-dimethoxy-3-hydroxymethylene oxindole (III). This oxindole (III) is then reacted with primary or secondary amines in refluxing benzene in the presence of acetic acid or toluene sulfonic acid to yield 5,6-dimethoxy-3-(substituted amino methylene) oxindoles (IV) or (V), respectively.
出典と根拠
- ORDレコード
- ord-0f88a97320c64033b9dbd7dfa764f397
- 出典データセット
- uspto-grants-1979_11
- 特許番号
- US04176191
反応ノート
読み込み中…