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Acetic Acid → 5,6-Dimethoxy-3[4(2-methylpropyloxycarbonyl)piperazino]methylene oxindole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Isobutyl piperazine-1-carboxylate | HCID 11788701 | — |
| 反応物 | HCID 178486553 | HCID 178486553 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5,6-Dimethoxy-3[4(2-methylpropyloxycarbonyl)piperazino]methylene oxindole | HCID 53951346 | — |
反応手順
5.00 g. of 5,6-Dimethoxy-3-hydroxymethylene oxindole, 2.5 g. acetic acid and 6.5 g. piperazine-N-carboxylic acid isobutyl ester (U.S. Pat. No. 3,635,979) in 40 ml. benzene was refluxed using a water separator to remove the water as it formed. After 20 minutes, 200 ml. benzene was added and the solution extracted with potassium carbonate and water. The benzene solution was treated with magnesium sulfate and charcoal, filtered, concentrated and the residue crystallized from isopropyl alcohol and ether to give 5.50 g. product, m.p. 195°-197° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04176191 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-72970bca4ce742a8bdfe7b556c92414c |
| 出典メモ | uspto-grants-1979_11 |