Potassium Hydroxide → Di-(4-methoxyphenyl)methyleneamino-oxyacetic acid

HRID 47082ノート

反応式

HRID 47082 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[N:18][O:19][CH2:20][C:21]([O:23]CC)=[O:22])[C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:5][CH:4]=1.[OH-].[K+]>C(O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[N:18][O:19][CH2:20][C:21]([OH:23])=[O:22])[C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 20385237Ethyl di-(4-methoxyphenyl)methyleneamino-oxyacetate

生成物 1

HCID 12942475Di-(4-methoxyphenyl)methyleneamino-oxyacetic acid収率 55%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of ethyl di-(4-methoxyphenyl)methyleneamino-oxyacetate (1.0 g.) in ethanol (20 ml.) and water (5 ml.) containing potassium hydroxide (1.0 g.) was left at ambient temperature for 16 hours. The solution was evaporated and the residue partitioned between ether and water. The aqueous layer was separated and acidified with concentrated hydrochloric acid. The mixture was extracted with ether, the extract dried (MgSO4) and evaporated to give di-(4-methoxyphenyl)methyleneamino-oxyacetic acid as a solid (0.5 g.), m.p. 105°-107° C. (55% yield).

後処理

  1. customThe solution was evaporated
  2. customthe residue partitioned between ether and water
  3. customThe aqueous layer was separated
  4. extractionThe mixture was extracted with ether
  5. dry with materialthe extract dried (MgSO4)
  6. customevaporated

出典と根拠

ORDレコード
ord-8dfd16dfa82e4d0dbd6eeb6d14cf08a0
出典データセット
uspto-grants-1979_11
特許番号
US04176194

反応ノート

読み込み中…