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2,5-Dimethoxytetrahydrofuran → 4-Phenoxy-3-(1H-pyrrol-1-yl)-5-sulfamoylbenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| 反応物 | 3-Amino-4-phenoxy-5-sulfamoylbenzoic acid | HCID 119927 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-Phenoxy-3-(1H-pyrrol-1-yl)-5-sulfamoylbenzoic acid | HCID 12881131 | — |
反応手順
A mixture of 3-sulphamoyl-4-phenoxy-5-amino-benzoic acid (3.08 g=10 mmols); P. W. Feit, J. Med. Chem. 14,432 (1971), 2,5-dimethoxy-tetrahydrofurane (1.32 g=10 mmols) and 5 ml of glacial acetic acid is refluxed for 15 minutes in an oil bath and evaporated to dryness in vacuo and the residue is recrystallised from ethyl acetate; the compound melts at 209°-210° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04176190 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-95cb7f59645a4f7aadd008677146636c |
| 出典メモ | uspto-grants-1979_11 |